Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs

Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation

The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms - ScienceDirect

Pathophysiological impact of the adhesion G protein-coupled receptor family

The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors - Morgan - 2019 - Annals of the New York Academy of Sciences - Wiley Online Library

The tethered peptide activation mechanism of adhesion GPCRs

Adhesion G Protein–Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms

Frontiers Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

Piconewton Forces Mediate GAIN Domain Dissociation of the Latrophilin-3 Adhesion GPCR

G protein-dependent and G protein-independent signaling by adhesion

The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces - Journal of Biological Chemistry